Lung fibrosis can also develop after viral infections and after exposure to radiotherapy, chemotherapeutic drugs, and aerosolized environmental toxins ( Denham and Hauer-Jensen, 2002 Kelly et al., 2002 Fubini and Hubbard, 2003 Chen and Stubbe, 2005). Idiopathic pulmonary fibrosis (IPF), a particularly severe form of pulmonary fibrosis with unknown etiology has a life expectancy of 2–6 yr after diagnosis ( Selman et al., 2001). It includes a heterogeneous group of lung disorders characterized by the progressive and irreversible destruction of lung architecture caused by scar formation that ultimately leads to organ malfunction, disruption of gas exchange, and death from respiratory failure. Pulmonary fibrosis is a lung disease that is refractory to treatment and carries a high mortality rate.
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